Asthma exacerbations during long term beta agonist use: influence of beta 2 adrenoceptor polymorphism
نویسندگان
چکیده
منابع مشابه
Asthma exacerbations during long term â agonist use: influence of â2 adrenoceptor polymorphism
Background—Polymorphisms of the â2 adrenoceptor influence receptor function in vitro and asthma phenotypes in vivo. However, their importance in determining responses to inhaled â agonist treatment has not been clearly defined. Methods—In a retrospective analysis of previously published data we have examined relationships between polymorphisms at codons 16 and 27 of the â2 adrenoceptor and clin...
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The prevalence of asthma in children has doubled over the past 25 years. Two common polymorphisms exist in the â adrenoceptor at amino acids 16 (glycine for arginine) and 27 (glutamic acid for glutamine). Both are functionally relevant in cultured cells, with the glycine 16 form of the receptor showing enhanced downregulation and the glutamic acid 27 form showing attenuated downregulation after...
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ژورنال
عنوان ژورنال: Thorax
سال: 2000
ISSN: 0040-6376
DOI: 10.1136/thorax.55.9.762